![]() Philadelphia, Pa.: Churchill Livingstone Elsevier 2014. New York, N.Y.: McGraw-Hill Education 2018. In: Current Diagnosis & Treatment: Pediatrics. Treatment and prognosis of neuroblastoma. Clinical presentation, diagnosis, and staging evaluation of neuroblastoma. Another rare syndrome causes abdominal swelling and diarrhea. Normally our pupils are relatively the same size. One paraneoplastic syndrome that occurs rarely in people with neuroblastoma causes rapid eye movements and difficulty with coordination. Anisocoria is a medical term for unequal pupil size. Neuroblastoma cells may secrete certain chemicals that irritate other normal tissues, causing signs and symptoms called paraneoplastic syndromes. Signs and symptoms caused by tumor secretions.Spinal cord compression may cause pain and paralysis. Tumors may grow and press on the spinal cord, causing spinal cord compression. Neuroblastoma may spread (metastasize) to other parts of the body, such as the lymph nodes, bone marrow, liver, skin and bones. ComplicationsĬomplications of neuroblastoma may include: ![]() In most cases of neuroblastoma, a cause is never identified. Yet, familial neuroblastoma is thought to comprise a very small number of neuroblastoma cases. Risk factorsĬhildren with a family history of neuroblastoma may be more likely to develop the disease. It isn't clear what causes the initial genetic mutation that leads to neuroblastoma. Others, however, form a tumor - a neuroblastoma. In most cases, these neuroblasts mature or disappear. Most neuroblasts mature by birth, though a small number of immature neuroblasts can be found in newborns. Neuroblastoma begins in neuroblasts - immature nerve cells that a fetus makes as part of its development process.Īs the fetus matures, neuroblasts eventually turn into nerve cells and fibers and the cells that make up the adrenal glands. The accumulating abnormal cells form a mass (tumor). Cancer cells grow and multiply out of control. In general, cancer begins with a genetic mutation that allows normal, healthy cells to continue growing without responding to the signals to stop, which normal cells do.
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